Science
Deliver a transformative medicine for untreated conditions with underactive bladder
Deliver a transformative medicine for untreated conditions with underactive bladder
- Underactive bladder (UAB) is characterized by a slow urinary stream, hesitancy and straining to void, with or without a feeling of incomplete bladder emptying sometimes with storage symptoms (*1)
- UAB is prevalent, underdiagnosed, and represents an unmet medical need in elderly and other populations. There are no outcome-validated effective therapeutics for UAB (*2)
SFG-02 is a novel investigational small molecule drug
- IND-enabling preclinical studies completed
- A novel formulation under development
- Phase 1 study in healthy volunteers to be initiated in 2025
(*1) Chapple CR, Osman NI, Birder L, et al. Terminology report from the International Continence Society (ICS) Working Group on Underactive Bladder (UAB). Neurourology and Urodynamics. 2018;1–4.
(*2) Chancellor MB, Bartolone SN, Lamb LE et al., Underactive Bladder; Review of Progress and Impact From the International CURE-UAB Initiative. Int Neurourol J. 2020; 24: 3–11.
Team
Masaki Yoshida
MD, PhD
Department of Urology
Sakurajyuji Hospital
Naoki Yoshimura
MD, PhD
Department of Urology
University of Pittsburgh
School of Medicine
Michael B. Chancellor
MD
Professor, Oakland University William Beaumont School of Medicine

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