Science

Deliver a transformative medicine for untreated conditions with underactive bladder

Deliver a transformative medicine for untreated conditions with underactive bladder

  • Underactive bladder (UAB) is characterized by a slow urinary stream, hesitancy and straining to void, with or without a feeling of incomplete bladder emptying sometimes with storage symptoms (*1)
  • UAB is prevalent, underdiagnosed, and represents an unmet medical need in elderly and other populations. There are no outcome-validated effective therapeutics for UAB (*2)

SFG-02 is a novel investigational small molecule drug

  • IND-enabling preclinical studies completed
  • A novel formulation under development
  • Phase 1 study in healthy volunteers to be initiated in 2025

(*1) Chapple CR, Osman NI, Birder L, et al. Terminology report from the International Continence Society (ICS) Working Group on Underactive Bladder (UAB). Neurourology and Urodynamics. 2018;1–4.
(*2) Chancellor MB, Bartolone SN, Lamb LE et al., Underactive Bladder; Review of Progress and Impact From the International CURE-UAB Initiative. Int Neurourol J. 2020; 24: 3–11.

Team

  • Leadership
  • Board of Directors
  • Advisors
  • Investors

Hiroshi Nagabukuro

Chief Executive Officer

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Dr. Hiroshi Nagabukuro is SFG’s co-founder, Chief Executive Officer (CEO) and board chair. Dr. Nagabukuro also serves as CEO of Juro Sciences, one of SFG’s portfolio companies. He brings over 25 years of industry experience, leading and building teams that have strong track records of discovering and developing novel therapeutics. Prior to SFG, he co-founded ARTham Therapeutics as COO/CSO followed by CEO role, and strategically and operationally led the company until its acquisition by Kaken Pharmaceutical in 2021. Before ARTham, Dr. Nagabukuro was Senior Director of Innovation & Entrepreneurship at Takeda, where he was heading the Entrepreneurship Venture Program and contributed launches of 9 different biotech companies. Prior to Takeda, he was Research Fellow at Merck Research Laboratories, where he led multiple target identification/validation and optimization programs and significantly contributed to the adrenergic β3 program, which resulted in the approval of vibegron for overactive bladder indication. Dr. Nagabukuro also serves as an Adjunct Professor at Tohoku University Hospital. He received his PhD from the University of Tokyo.

Akira Tanaka

Chief Scientific Officer

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Dr. Akira Tanaka is a SFG’s co-founder, serves as Chief Scientific Officer and a board director. Before the inception of SFG, Dr. Tanaka was the Vice President of Clinical Science at ARTham Therapeutics where he led the clinical development, conducted Phase I and Phase II studies for two products, and contributed to obtaining a POC for one of them. Prior to ARTham, he worked in preclinical drug discovery research as a pharmacologist at Takeda and thereafter in clinical development as a clinical scientist in gastrointestinal therapeutic area at Takeda Boston site. He received his PhD from the University of Tsukuba.

Hiroshi Nagabukuro

Chief Executive Officer

linkedin

Dr. Hiroshi Nagabukuro is SFG’s co-founder, Chief Executive Officer (CEO) and board chair. Dr. Nagabukuro also serves as CEO of Juro Sciences, one of SFG’s portfolio companies. He brings over 25 years of industry experience, leading and building teams that have strong track records of discovering and developing novel therapeutics. Prior to SFG, he co-founded ARTham Therapeutics as COO/CSO followed by CEO role, and strategically and operationally led the company until its acquisition by Kaken Pharmaceutical in 2021. Before ARTham, Dr. Nagabukuro was Senior Director of Innovation & Entrepreneurship at Takeda, where he was heading the Entrepreneurship Venture Program and contributed launches of 9 different biotech companies. Prior to Takeda, he was Research Fellow at Merck Research Laboratories, where he led multiple target identification/validation and optimization programs and significantly contributed to the adrenergic β3 program, which resulted in the approval of vibegron for overactive bladder indication. Dr. Nagabukuro also serves as an Adjunct Professor at Tohoku University Hospital. He received his PhD from the University of Tokyo.

Akira Tanaka

Chief Scientific Officer

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Dr. Akira Tanaka is a SFG’s co-founder, serves as Chief Scientific Officer and a board director. Before the inception of SFG, Dr. Tanaka was the Vice President of Clinical Science at ARTham Therapeutics where he led the clinical development, conducted Phase I and Phase II studies for two products, and contributed to obtaining a POC for one of them. Prior to ARTham, he worked in preclinical drug discovery research as a pharmacologist at Takeda and thereafter in clinical development as a clinical scientist in gastrointestinal therapeutic area at Takeda Boston site. He received his PhD from the University of Tsukuba.

Hiroyuki Misawa

Board Member

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Dr. Hiroyuki Misawa is a Partner at Miyako Capital and serves as an Outside Director of Juro. Prior to joining Juro, he was involved in ARTham Therapeteutics from its inception as a lead investor and supported ARTham’s management as an Board Director. In 2014, he joined Miyako Capital in its early stages, where he is responsible for investments in the bio-healthcare sector. He has invested in a wide range of areas from regenerative medicine and drug discovery to medical devices and health-related services, and has been involved in several IPOs and M&A deals. Hiroyuki received his PhD from Saitama University Graduate School.

Ayako Kaiho

Auditor

Ms. Ayako Kaiho is the external company auditor. Having over thirty years of experiences in management and governance as a founder, a member of operating management team or a consultant to hospital, consumer product and financial industries, she has gained confidence in building and helping new business and securing the clarity and sustainability of operation. Her working experiences in the US also contributed to those projects with global talents of diversified expertise and background. Most recently Ms. Kaiho has served as the board member of Kato Sangyo, a prime market listed food wholesaler. She received the bachelor’s degree in finance from New York University.

Masaki Yoshida

MD, PhD

Department of Urology
Sakurajyuji Hospital

Naoki Yoshimura

MD, PhD

Department of Urology
University of Pittsburgh
School of Medicine

Michael B. Chancellor

MD

Professor, Oakland University William Beaumont School of Medicine

JURO SCIENCES Inc.

Yamashita-cho 24-8, Naka-kuYokohama 231-0023 JAPAN

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